How to do heavy computational lifting in genomes and transciptomes

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You've sequenced 50 million tiny strings of nucleotides. Then w

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The Scientist , Jun 8 - You've unpacked your next-generation sequencing system and popped in some DNA or RNA. Five days later, you've sequenced 50 million tiny strings of nucleotides. Then what? Tolerating Mismatches USER: Nicholas Bergman, assistant professor of biology, Georgia Institute of Technology, Project: Mapping the transcriptome of anthrax-causing bacteria (Bacillus anthracis) and measuring gene expression levels Bergman's group uses Applied Biosystems' SOLiD gene sequencer, because it produces more data than do other new platforms... "It would take [an inaccuracy] and say this read is unmappable," Bergman says. The group needed a new algorithm that would tolerate these errors and move through vast amounts of data.

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The Scientist , Jun 8 - You've unpacked your next-generation sequencing system and popped in some DNA or RNA. Five days later, you've sequenced 50 million tiny strings of nucleotides. Then what? Tolerating Mismatches USER: Nicholas Bergman, assistant professor of biology, Georgia Institute of Technology, Project: Mapping the transcriptome of anthrax-causing bacteria (Bacillus anthracis) and measuring gene expression levels Bergman's group uses Applied Biosystems' SOLiD gene sequencer, because it produces more data than do other new platforms... "It would take [an inaccuracy] and say this read is unmappable," Bergman says. The group needed a new algorithm that would tolerate these errors and move through vast amounts of data. (Full Story)

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  • Created By: Troy Hilley
  • Workflow Status: Archived
  • Created On: Jul 1, 2009 - 8:00pm
  • Last Updated: Oct 7, 2016 - 11:11pm