*********************************
There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
*********************************
Prof. Joan-Emma Shea, University of California, Santa Barbara
Simulations of protein aggregation
A number of diseases, known as amyloid diseases, are associated with pathological protein folding. In the case of Alzheimer's disease, incorrectly folded Amyloid-beta (Aβ) proteins self-assemble into a variety of neurotoxic aggregate species, ranging from small soluble oligomers to amyloid fibrils. An attractive therapeutic approach to combat amyloid diseases lies in the development of strategies to inhibit or reverse aggregation. In the first part of my talk, I will present fully atomistic molecular dynamics simulations of the interaction of aggregation inhibiting peptides with Aβ amyloid fibrils. In the second part, I will introduce a novel off-lattice coarse-grained model for the Aβ protein and discuss the kinetics and thermodynamics of aggregation and fibrillogenesis inhibition.
For more information contact Dr. Christine Payne, (404) 385-3125.
