*********************************
There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
*********************************
Prof. Tadhg Begley, Texas A&M University
Thiamin biosynthesis: characterization of two genes of unknown function
School Colloquia
Thiamin pyrophosphate plays a key role in the stabilization of the acyl carbanion biosynthon in carbohydrate and amino acid metabolism and is an essential cofactor in all living systems. The biosyntheses of the thiamin pyrimidine and thiazole are complex and differ from any of the characterized chemical or biochemical routes to these heterocycles. The complete thiamin biosynthesis has now been reconstituted in a biochemically-defined system and the structures of all of the biosynthetic enzymes have been determined. Our mechanistic understanding of the pathway is also at an advanced stage.
This presentation will describe recent progress on the functional characterization of the TenA and TenI genes involved in thiamin biosynthesis.
For more information contact Prof. Wendy Kelly (404-385-1154).
