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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Prof. Kevin Bucholtz, Mercer University
PPAR δ and 3β-HSD1: Two Stories in Ligand Selectivity
Organic Chemistry Seminar Series
Peroxisome Proliferator Activated Receptors (PPAR) are nuclear hormone receptors that are of great interest because of their implications in the metabolic syndrome. The isotype PPAR δ, a ligand activated transcription factor, is of significant interest since little is known about its role in biological phenomena. The human type isoform of 3β-hydroxysteroid dehydrogenase/ isomerase (3β-HSD1) is a key enzyme in the biosynthesis of active steroid hormones. Human 3β-HSD1 is a critical enzyme in the conversion of dehydroepiandrosterone (DHEA) to estradiol in breast tumors. Both of these biomacromolecules (PPAR δ and 3β-HSD1) have been the focus of rationally designed small molecules to selectively interact with each target and used to determine the characteristics of the interaction. The biological implications of these small molecule interactions are currently being investigated.
for more information contact Prof. Wendy Kelly (404-385-1154).
