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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Prof. Indraneel Ghosh, University of Arizona
When it Takes Three to Tango: Ternary Design Paradigms for Sensors and Inhibitors
The central motivation of our research program is to develop methodologies that have the potential for illuminating chemistry in a biological context. Towards his goal, I will describe new paradigms for designing supramolecular protein and peptide architectures that can serve as:
I)Turn-on split-protein sensors that are designed to respond to a variety of macromolecular targets. Our current targets include DNA, RNA, and proteins/enzymes.
II) Bivalent Inhibitors for selectively targeting protein surfaces, particularly protein kinases.
For more information contact Prof. Seth Marder (404-385-6048).
