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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Dr. Qiu Wang, The Broad Institute, Harvard/MIT
Leveraging Small Molecules for Biology and Therapy - discovery of novel tetracycline antibiotics and inhibitors of histone lysine methyltransferases
Small-molecule probes serve as unique tools to study biological questions and offer great promise toward therapeutic applications. This talk will present two examples using complementary strategies to develop small-molecule probes, including: (1) the discovery of novel tetracycline antibiotics to overcome the drug resistance in a âtop-downâ approach; and (2) the identification of small-molecule inhibitors of histone lysine methyltransferases in a âbottom-upâ fashion. The principles in synthetic chemistry, assay development, genetics and proteomics have been integrated to facilitate the discovery of such useful probes. Especially, synthetic efforts, such as the synthesis of complex molecules and the development of novel chemical transformations, have been playing an important role.
