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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Prof. Martin Zanni, University of Wisconsin-Madison
New technology for 2D IR spectroscopy and its application to protein aggregation and drug binding
Physical Chemistry Seminar Series
In just the last couple of years, 2D IR spectroscopy has evolved into a useful tool in the chemical, biological and energy sciences. In this talk, I will describe experiments in which we have used 2D IR spectroscopy and isotope labeling to determine, with residue-specificity, the binding mechanism and structure of an amyloid inhibitor that prevents the formation of amylin amyloid fibers, which is the polypeptide associated with type 2 diabetes. I will also present work in which we have used expressed protein ligation to uniformly isotope label an entire domain of a crystallin protein involved in cataract formation, from which we study its aggregate structure and kinetics. Finally, I will present a recent technological development that paves the way to commercialization of a 2D IR spectrometer.
For more information contact Prof. Christine Payne (404-385-3125).
