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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Prof. Greg Challis, University of Warwick, UK
Elucidating and exploiting novel biosynthetic C-H functionalization reactions
Joint Biochemistry/Organic Divisions Seminar
The selective functionalization of C-H bonds is a “holy grail” of chemistry that is attracting considerable current interest. The biosynthetic pathways to numerous bioactive natural products involve highly selective C-H functionalization reactions that are difficult or impossible to mimic using man-made catalysts. The discovery and mechanistic investigation of novel enzymes that mediate remarkable C-H functionalization reactions in the biosynthesis of antimalarial and phytotoxic natural products will be described. Efforts to exploit these enzymes for the production of novel natural product analogues will be summarised.
For more information please contact Prof. Wendy Kelly (404-385-1154).