*********************************
There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
*********************************
Summary Sentence: Arnold Ju and Dhaval Patel presenting
Full Summary: Graduate and Postdoc (GaP) Seminar Series - Arnold Ju and Dhaval Patel presenting
GaP Seminar Series
Arnold Ju
Dhaval PatelArnold Ju - Advisor, Cheng Zhu, PhD
Biophysical Regulation of Binding Kinetics of Platelet Glycoprotein Ibα with von Willebrand Factor
The interaction of platelet glycoprotein Ibα (GPIbα) with von Willebrand factor (VWF) mediates the tethering and rolling of platelets on disrupted vascular surfaces during the hemostatic and thrombotic processes. By monitoring the reduction in thermal fluctuations of a biomembrane force probe, we visualized in real time repeated formation and dissociation of bonds between GPIbα and VWF A1 domain from which the on- and off-rates were derived.
Dhaval Patel - Advisor, Lakeshia Taite, PhD
Engineering Adaptable ECM-Copolymer Hydrogels To Facilitate Vascular Development
Two elastin mimetic peptides, EM-19 and EM-23, were engineered to promote vascular ECM deposition over PEGDA surfaces. Once grafted on a PEGDA hydrogel, EM-23, AAKAAKVGVAPGRGDSAAKAAKK, was able to increase SMC adhesion over EM-19, AAKAAKVGVAPGAAKAAKK, and RGDS. Elastin production on gels grafted with EM-23 was comparable to TCPS suggesting that EM-23 is able to promote vascular ECM production.
The Graduate and Post-Doc (GaP) Seminar Series is a weekly event of biotechnology related research presentations by two graduate students or post-docs of IBB and is co-sponsored by BME. It is held every Wednesday at 12:00pm in IBB 1128 and refreshments are provided. If your research group or department would like to present at future seminars, please contact Manu Platt, PhD at manu.platt@bme.gatech.edu.
