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Abstract: Recent evidence in different physiological systems supports a theory of complexity-loss, which states that the complexity carried out by physiological outputs breaks down with aging and disease. In this talk, we will briefly discuss entropy-based complexity metrics, particularly the multi-scale entropy (MSE) method, and we will illustrate the MSE analysis applied to the detection of Alzheimer’s disease (AD) through the eye. We performed ex vivo electroretinogram (ERG) measurements in an animal model of AD, the transgenic 5xFAD, and found that the complexity of the ERG, as estimated using the MSE, was smaller than that of wild-type animals. Further, the difference depended on both the age of the animals and the type of stimulus used to elicit ERG responses. These results can have great implications for the diagnosis of neurodegenerative diseases via the eye.
About the speaker: Leonel E Medina is an Assistant Professor at Universidad de Santiago de Chile. Trained in electrical engineering, Dr. Medina received a PhD in Biomedical Engineering from Duke University. His research seeks to advance electrical neuromodulation therapies by means of computational modeling and engineering techniques, as well as engineering tools and analyses to understand neural system function.
Date: Feb 17, 11 AM to 12 PM
Location: Emory-HSRB-1 (Room E160) and Zoom (see info below).
https://zoom.us/j/97421219805?pwd=b2ZUZElTQ044anlVbFRib2VIQk1IQT09
Meeting ID: 974 2121 9805
Passcode: 556677
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