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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Title:
DNA G-quadruplex: Structures, Functions, and Drug Targeting
Abstract:
DNA G-quadruplex secondary structures formed in guanine-rich human telomeres and oncogene promoters are functionally important and have emerged as a promising new class of cancer-specific drug targets. I will presnet structural and functional studies in our lab related to the biologically relevant DNA G-quadruplexes formed in human telomeres and oncogene promoters as well as their interactions with small molecules and proteins. Structural information of G-quadruplexes in complex with small-molecules is critical for understanding specific recognition and structure-based rational drug design.I will also present critical insights and conceptual advances that help our understanding of G-quadruplex structures, functions, and drug targeting.
