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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Summary Sentence: Biological Sciences Seminar by Rabindranath De La Fuente DVM., Ph.D.
Full Summary: No summary paragraph submitted.
Rabindranath De La Fuente Seminar FlyerRabindranath De La Fuente DVM., Ph.D.
Department of Physiology and Pharmacology
University of Georgia
ABSTRACT
Cellular senescence is a major contributor to tissue dysfunction and age-related decline in organismal health.The molecular mechanisms regulating changes in the chromatin landscape during cellular senescence are not fully understood. However, accumulating evidence indicates that changes in chromatin structure and function induced by altered epigenetic profiles are important contributing factors to the onset of cellular aging and predispose a cell to chromosome instability in the form of aneuploidy, deletions and translocations.The chromobox homologue protein 2 (CBX2) is a critical component of the Polycomb Repressive Complex (PRC1). CBX2 is an important epigenetic reader involved in the regulation of cell proliferation and differentiation that is overexpressed in a wide range of human tumors.However, its cellular and molecular function(s) are only beginning to be unraveled.This seminar will presentongoing projects andrecent findingson the role of CBX2 in maintenance of chromosome stabilityas well as the potential mechanisms leading to the onset of premature senescence in CBX2 knockout mouse cells.
Host: Yuhong Fan, Ph.D.
