Frontiers Lecture: Dr. Lynn Kamerlin

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Event Details
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Summaries

Summary Sentence: "Harnessing Conformational Dynamics and Computational Design to Engineer New Enzymes"

Full Summary: Abstract: Understanding how new enzyme functions evolve, either on existing scaffolds, or completely de novo on previously non-catalytic scaffolds, is of great interest both from a fundamental biochemistry perspective, and from a biotechnological perspective. Several hypotheses have been put forward to rationalize enzyme evolution, one of which is that their conformational dynamics plays an important role in facilitating the emergence of new enzyme functions. My team and I have invested substantial research effort into understanding enzyme multifunctionality in catalytically promiscuous enzymes, as well as the structure-function-dynamics relationships shaping the evolution of new enzyme functions, in both natural and engineered active sites. In this talk, I will discuss recent progress in this area, and illustrate how we have engineered conformational dynamics to generate a de novo active site capable of catalysing a non-natural reaction, and then subsequently enhanced this activity using a simple computational approach, reaching catalytic efficiency comparable to that of naturally occurring enzymes.

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In Campus Calendar
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Groups

School of Chemistry and Biochemistry

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Faculty/Staff, Public, Undergraduate students
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Status
  • Created By: arcs-stuweb03
  • Workflow Status: Published
  • Created On: Mar 9, 2022 - 2:03pm
  • Last Updated: Mar 9, 2022 - 2:16pm