*********************************
There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
*********************************
THE SCHOOL OF MATERIALS SCIENCE AND ENGINEERING
GEORGIA INSTITUTE OF TECHNOLOGY
Under the provisions of the regulations for the degree
DOCTOR OF PHILOSOPHY
on Tuesday, April 13, 2021
1:00 PM
via
BlueJeans Video Conferencing
https://gatech.bluejeans.com/447437285
will be held the
DISSERTATION DEFENSE
for
Chen Jiang
"Design, Fabrication and Characterization of Electrospun Fibers, Yarns, and Scaffolds for Textile-inspired Tissue Engineering"
Committee Members:
Prof. Ben Wang, Advisor, ISYE/MSE
Prof. Preet Singh, MSE
Prof. Naresh Thadhani, MSE
Kevin Wang, Ph.D., GTMI
Prof. Youjiang Wang, MSE
Abstract:
This dissertation focuses on the design, fabrication, and characterization of electrospun fibers, yarns, and scaffolds, which are building blocks of textile-based tissue engineering, an important field in regenerative medicine. This study proved the hypothesis that textile-based tissue engineering would yield artificial tissues with similar physical, biological, and mechanical properties as their natural counterparts. For fibers, I investigated cell adhesion, proliferation, and morphology on electrohydrodynamic (EHD) direct-written fibers with controllable surface roughness. The results provided guidelines about controlling the surface roughness of single fibers to achieve desirable cell responses. For yarns, I investigated the mechanism of wet electrospinning and fabricated yarns with controllable mechanical properties. For scaffolds, I assembled wet electrospun yarns into scaffolds via textile technology for two case studies. The results indicated that the textile-based scaffolds could satisfy the physical, biological, and mechanical requirements for skin and vascular tissue engineering. This study will enhance the robustness of textile technology in tissue engineering and provide new perspectives for the design and fabrication of scaffolds. The modified electrospinning technology will greatly extend the usefulness of electrospinning in tissue engineering and related fields.
