*********************************
There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
*********************************
CSSB Distinguished Lecturer Series
Abstract:
In eukaryotic cells, small RNA molecules regulate the expression of many genes. The enzyme Dicer plays a central role in producing these RNAs and ensuring that they assemble with other proteins into effector complexes. Recent findings show that Dicer and its partner RNA binding proteins can alter miRNA processing to change the set of mRNAs targeted for silencing. Although Dicer homologs do not occur in prokaryotic cells, bacteria possess distinct sets of enzymes that produce short RNA molecules to block the propagation of viral and plasmid sequences. In bacteria, these regulatory RNAs are produced from clustered regularly interspaced short palindromic repeats (CRISPRs). I will discuss our recent work to uncover the molecular basis for small RNA production and targeting. We also find interesting similarities in the thermodynamics of target recognition between RNAi-type and CRISPR-type systems.
Additional Info:
Research Interests: RNA molecules are uniquely capable of encoding and controlling the expression of genetic information, often as a consequence of their three-dimensional structures. We are interested in understanding RNA-mediated initiation of protein synthesis, and RNA-protein complexes involved in targeting proteins for export out of cells. We are also investigating the early steps in gene regulation by RNA interference.
Jeffrey Skolnick - faculty host
