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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Bluejeans link for the seminar is available here.
Contact Daniel Muratore (here) for questions.
Summary Sentence: QBioS Student Seminar Series - Mengshi Zhang
Full Summary: QBioS 4th year student Mengshi Zhang (homeschool of biological sciences), advised by Marvin Whiteley, will present "Quantification of mRNA and protein and integration with their half-life dynamics in Aggregatibacter actinomycetemcomitans"
02_25_qbios_seminar_flyerQuantification of mRNA and protein and integration with their half-life dynamics in Aggregatibacter actinomycetemcomitans
Bacterial gene expression and regulation mainly involves coupled processes of transcription, translation and degradation of messenger RNAs (mRNAs) and proteins. Limited efforts have been made to quantify the combined effects of these gene regulatory events globally. Here we aim to understand genome-wide gene expression control and to evaluate if RNA level is a good proxy to predict protein abundance in model organisms. I first analyzed the correlation of mRNA and protein abundance in Pseudomonas aeruginosa (PA). Our PA data suggest that mRNA abundance alone cannot precisely predict protein abundance (~60%). I also measured mRNA and protein expression profiles in Aggregatibacter actinomycetemcomitans (Aa) using RNA-seq and mass spectrometry approaches, and will integrate with their half-life dynamics for thousands of genes (work in progress). These studies provide a quantitative analysis of the cellular abundance and turnover dynamics of mRNA and protein and help us understand the underlying principles of gene expression control.
The seminar will be hosted at this bluejeans link.
