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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Bluejeans link for the seminar is available here.
Contact Daniel Muratore (here) for questions.
Summary Sentence: QBioS Seminar Series - Guanlin Li
Full Summary: QBioS 4th year student Guanlin Li (homeschool of physics), advised by Joshua Weitz, will present "Optimizing use of multiphage ‘cocktails’ for treatment of immunodeficient hosts: a model-based control approach"
qbios_seminar_02_11_2021_flyerOptimizing use of multiphage ‘cocktails’ for treatment of immunodeficient hosts: a model-based control approach
The addition of therapeutic phage to treat Multi-Drug Resistant (MDR) pathogens imposes a strong selective pressure for the emergence of phage-resistant bacteria. Modeling and in vivo experiments have established that phage-resistant bacteria proliferate in Myd88-/- (immunodeficient) mice, corresponding to a failure of phage therapy. This work aims to develop evolutionarily robust phage therapy in immunodeficient hosts. First, we consider a model where bacteria evolve in an abstract discrete phenotypic space against different types of phages present in a therapeutic phage library. Second, we formulate a single-dose optimization problem subject to the proposed eco-evolutionary dynamics. The goal is to minimize the total bacterial population while penalizing the treatment costs by optimizing the phage therapy administrations. Finally, we extend single-dose treatment to multi-dose treatment and find the optimal policy via control theory.
This seminar will be hosted at this bluejeans link.
