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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Fatiesa Sulejmani
BME PhD Thesis Defense Presentation
Date: Wednesday, November 30th, 2020
Time: 8:30 – 10:00 AM
BlueJeans Link: https://bluejeans.com/212595910
Meeting ID: 212 595 910
Advisor: Wei Sun, Ph.D.
Committee Members:
Yunlong Huo, Ph.D.
Ajit Yoganathan, Ph.D.
Rudolph Gleason, Ph.D.
Glen Iannucci, M.D.
Title: Biomechanical Assessment of Tricuspid Regurgitation Using Experimental and Computational Approaches
Abstract:
Functional Tricuspid Regugitation (FTR) accounts for over 80% of all incidences of tricuspid regurgitation (TR) and affects over 1.6 million Americans. The current gold standard treatment approach is the implantation of an annuloplasty ring; however, due to late diagnosis, many patients are deemed as too high risk for surgery and only 1% of such patients receive surgical intervention every year. Several percutaneous approaches are under development and undergoing human subject testing in compassionate uses cases, but their mechanical effects on the tricuspid apparatus are currently unknown and may provide valuable information regarding device durability and tissue remodeling.
The twofold objective of this study was therefore to characterize the mechanics of the right ventricle (RV) and of TR repair and develop patient-specific computational models of the percutaneous and surgical approaches in order to better understand and compare the mechanics of these methodologies on TR patients. This study was divided into two aims: in Aim 1, the mechanical properties of right heart tissues in human patients were characterized and an experimental replication of the percutaneous bicuspidization technique was developed to quantify the mechanics and geometry of the cinching techniques on these same hearts. In Aim 2, this technique was applied to computational models for patient-specific surgical planning in real TR patients by simulating the surgical and percutaneous approaches for mechanical investigation. It is expected that the results of these studies may serve to inform further TR device design and development and offer mechanical explanations for observed post-procedural outcomes.
