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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Hansang Cho, Ph.D.
Assistant Professor
Department of Mechanical Engineering
Sungkyunkwan University & University of North Carolina at Charlotte
“3D Human Brain models in Microfluidics for the Study of Neurological Disorders”
With hundreds of billions of neurons and thousands of trillions of synaptic connections between them, the human brain is the most complex system on earth. However, there are no well-developed human brain models to study the brain activities in either laboratory environments or in animal bodies. Here, I present micro-scaled 3D environments that reconstruct a 3D human brain in Alzheimer’s disease (AD) by recapitulating AD signature of elevated levels of amyloid-beta (A-beta), tau proteins, activation of microglia, immune cells resident in a central nervous system (CNS), and consequent neuronal damage. In particular, the model mirrored microglial neurotoxic activities such as axonal cleavage and neurotoxic release.
Lunch will be provided at the beginning of the seminar.
