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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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The Biological Sciences Seminar featuring Jianlong Wang, originally scheduled for March 26, 2020, has been postponed. Please visit biosci.gatech.edu for further updates.
Jianlong Wang, Ph.D.
Columbia Center for Human Development,
Columbia University Irving Medical Center
ABSTRACT
Molecular control of stem cell and developmental potencyresides in a core circuitry of master transcription factors that act in conjunction with epigenetic cofactors for activation and repression of downstream target genes. We have employedboth genomic and proteomic approaches as well as mouse models to study protein-protein interaction and protein-DNAregulatory networks that govern embryonic stem cell (ESC) pluripotency, somatic cell reprogramming, and embryogenesis. Our long-term goal isto understand how cell identity is established, maintained, and altered during mammalian (both mouse and human) developmentunder both normal and pathological conditions. In my talk, I will discussour published and unpublished work dissecting molecular mechanismsunderlying ESCpluripotency, somatic cell reprogramming, and totipotency-to-pluripotency transition during early development.
Host: Yuhong Fan
