*********************************
There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
*********************************
Title: Negative Enrichment of Circulating Tumor Cells Via 3D Printed Microfluidic Device
Committee:
Dr. Sarioglu, Advisor
Dr. Emelianov, Chair
Dr. Frazier
Abstract:
The objective of the proposed research is to develop a 3D printed microfluidic device for the enrichment of circulating tumor cells. Microfluidic devices that utilize immunoaffinity-based leukocyte depletion offers high specificity and unbiased circulating tumor cell enrichment. In this proposal, I will present a 3D printed monolithic device with stacked layers of immunodepletion channels followed by a microfiltration section to deplete leukocytes directly from whole blood and retrieve the cancer cells, respectively. In the proposed work, I will focus on the development of a custom filter membrane to further deplete the leukocytes and increase the purity of the enriched circulating tumor cells while looking into different mechanical cell sorting mechanism that can be implemented in the upstream of the device to further increase the depletion rate of the leukocyte in the immunodepletion channels.
