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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Abstract: The cellular phenotypes caused by inherited arrhythmia mutations have been studied using human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs). However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of these mutations on tissue-level properties of human myocardium has not been reported. In this talk, I will present an in vitro hiPSC-CM-based platform to study the tissue-level properties of engineered human myocardium. I will illustrate how this hiPSCCM- based platform can be used to investigate pathogenic mechanisms in the deadly, exercise-triggered inherited arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT). In addition, I will show how we combined this novel platform with genome editing and identified new therapeutic target for CPVT.
Lunch Provided at 1pm
RSVP link: https://forms.gle/5VV1PzeduPaUBEKg8
BlueJeans: https://bluejeans.com/870397059
