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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Functional and comparative genomic analysis of integrated prophage-like sequences in CLas by Marian Dominguez
Huanglongbing (HLB; yellow shoot disease) is a severe worldwide infectious disease for citrus family plants. The pathogen Candidatus Liberibacter asiaticus (CLas) is an alphaproteobacterium of the Rhizobiaceae family that has been identi ed as the cause. The virulence of CLas has been attributed, in part, to prophage encoded genes. Prophage and prophage-like elements have been identified in 12 of the 15 CLas available genomes, and are classified into three prophage types. We re-examined all 15 CLas genomes using a de novo prediction approach and expanded the number of prophage-like elements from 16 to 33. Further, we find that all CLas contain at least one prophage-like sequence. Comparative analysis reveals a prevalent, albeit previously unknown, prophage-like sequence type that is a remnant of an integrated prophage. Notably, this remnant prophage is found in the Ishi-1 CLas strain that had previously been reported as lacking prophages. Our findings provide both a resource and new insights into the evolutionary relationship between phage and CLas pathogenicity.
