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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Atlanta, GA | Posted: June 26, 2019
Phil Santangelo has been promoted to full professor effective August 15, 2019.
Research in Phil Santangelo’s lab is primarily focused on three areas: native RNA regulation, RNA virus pathogenesis, and RNA therapeutics and vaccines, where the application and development of imaging technology is applied to all three areas.
To address RNA regulation, localization and dynamics in the cellular milieu, his lab developed single molecule sensitive approaches for imaging native RNAs and RNA dynamics in live cells, as well as the first assay to detect native RNA-protein interactions in situ. To date, the results of these methods have been applied to the cell biology of human respiratory syncytial virus infections and RNA regulation during tumorigenesis.
His lab’s methods and their results have been published in high impact journals such as Nature Methods, Nature Nanotechnology, ACS Nano, Traffic, Journal of Virology, Nucleic Acids Research, and Journal of Biological Chemistry. These methods are also being used to interrogate and develop RNA-based therapeutics and vaccines.
In addition he has been developing whole-body, PET/CT imaging tools for interrogating SIV infections within the macaque model. The purpose of this tool is to answer fundamental questions regarding the location of residual virus during treatment, in the hope of learning vital information that could be applied to approaches seeking to “cure” SIV or HIV.