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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Our understanding of how genomes are organized inside the interphase nucleus, and of the molecular factors involved, is rapidly improving. In this talk, first, I will review some of the recent research that has led to this current understanding. However, I will then present a number of results, including measurements of chromatin dynamics in living cells, that challenge aspects of this picture. I will then develop and explore a modified hypothesis for the mechanisms underlying genome organization. Finally, I will compare the consequences of our modified model of chromatin organization to genome-wide experimental data.