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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Among the first microarray experiments were those measuring expression over time, and time course experiments remain common. Most methods to analyze time course data attempt to group genes sharing similar temporal profiles within a single biological condition. However, with time course data in multiple conditions, a main goal is to identify differential expression patterns over time. I will present a Hidden Markov modeling approach designed specifically to address this question. Simulation studies show a substantial increase in sensitivity without an increase in the false discovery rate when compared to a marginal analysis at each time point. Results from three case studies will be discussed.
