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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Elena Dimitrova, Clemson University
Thursday,January 31
11:00 am
Skiles 005
“Control through canalization in modeling the innate immune response to ischemic injury”
Abstract:
Constriction of blood vessels in the extremities due to traumatic injury to halt excessive blood loss or resulting from pathologic occlusion can cause considerable damage to the surrounding tissues with significant morbidity and mortality. Optimal healing of damaged tissue relies on the precise balance of pro-inflammatory and pro-healing processes of innate inflammation. In this talk, we will present a discrete multiscale mathematical model that spans the tissue and intracellular scales, and captures the consequences of targeting various regulatory components. We take advantage of the canalization properties of some of the functions, which is a type of hierarchical clustering of the inputs, and use it as control to steer the system away from a faulty attractor and understand better the regulatory relations that govern the system dynamics.
Host: Melissa Kemp
