PhD Proposal by Xiangxi Meng

*********************************
There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
*********************************

Event Details
  • Date/Time:
    • Monday September 10, 2018 - Tuesday September 11, 2018
      9:00 am - 10:59 am
  • Location: UAW 4235 (GT), Wangkezhen Bldg 908 (PKU)
  • Phone:
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact
No contact information submitted.
Summaries

Summary Sentence: Multiplexed Molecular Imaging in the Second Near-Infrared Window

Full Summary: No summary paragraph submitted.

Xiangxi Meng

BME PhD Proposal Presentation

 

Date: Monday, September 10

Time: 9 AM

Location: UAW 4235 (GT), Wangkezhen Bldg 908 (PKU)

 

Committee members:

Qiushi Ren (Advisor)

May D. Wang (Co-Advisor)

Weiqiang Chen

Changhui Li

Shuming Nie

 

Multiplexed Molecular Imaging in the Second Near-Infrared Window 

The second near-infrared window (NIR-II window) is a certain range of near-infrared light with superior ability to penetrate biological tissues. In this research, the basic imaging properties of the NIR-II imaging were first explored. To enable this, equipment for conducting NIR-II imaging were constructed and corresponding fluorescent materials were prepared. Liquid phantoms with Intralipid were used as a model system to verify the imaging ability, and the results obtained were verified with a CLARITY experiment. After obtaining such results, new methods to multiplex NIR-II fluorescence imaging and other biomedical procedures were proposed and explored. Taking the advantage of its special penetration ability, NIR-II imaging could be used to look into the transient process of the first several seconds of the distribution of fluorescent quantum dots administered via tail-vein injection. NIR-II imaging was also used to visualize the intestine structure and bowel movement real-time on nude mice. Furthermore, NIR-II imaging could be used in the tracking of stem cells inside a mouse brain. In the end, by multiplexing with radiotherapy, which generates Cerenkov photons, the NIR-II emitting quantum dots can be illuminated. This may provide a tool to help the precision delivery of dosage and real-time monitoring of the radiotherapy process. In this research, the potential of NIR-II imaging is explored, and the multiplexing ability of NIR-II imaging is demonstrated. 

Additional Information

In Campus Calendar
No
Groups

Graduate Studies

Invited Audience
Faculty/Staff, Public, Graduate students, Undergraduate students
Categories
Other/Miscellaneous
Keywords
Phd proposal
Status
  • Created By: Tatianna Richardson
  • Workflow Status: Published
  • Created On: Sep 5, 2018 - 3:14pm
  • Last Updated: Sep 5, 2018 - 3:14pm