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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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ABSTRACT
Stem cell-derived organoids promise broad translational potential for applications ranging from drug screening to transplantation and regeneration. These complex, and often functional, tissue-like structures arise largely from endogenous patterning and morphogenesis of pluripotent stem cells within three-dimensional spheroids. Our research efforts aim to control and perturb these processes through a quantitative understanding of stem cell fate dynamics and engineering of the biophysical spheroid microenvironment. This seminar will present insights into the integration of extrinsic stimuli, cell intrinsic cues and signaling mechanisms, raising questions on how to establish design parameters and judiciously perturb these complex stem cell systems.
Host: Melissa Kemp