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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Kathryn Murray
Master’s Defense Presentation
Date: Tuesday August 15th, 2017
Time: 12:30-2:30pm EST
Location: Engineered Biosystems Building (EBB) room 4029
Committee Members:
Todd Sulchek, PhD (Advisor, GT ME/BME)
Julie Champion, PhD (GT ChBE)
Ravi Kane, PhD (GT ChBE/BME)
Title:
Fabrication and characterization of multifunctional particles with spatially segregated proteins
Abstract:
Multifunctional particles have been of great interest in a variety of fields including electronics, biology, chemistry, and medicine. In therapeutic design, they can allow for site specific targeting, monitoring of delivery as well as the ability to carry multiple immiscible drugs on a single particle at once. Despite the many advances in multifunctional particles, there are still very few methodologies which allow for spatial control of multiple chemical and biological ligands on a single particle. In this thesis, a novel method has been explored to fabricate a three-sided "Cerberus" particle using repeated glancing angle metal evaporation on microparticles. Silica particles of varying diameters are surface-modified with two metals creating chemically distinct regions which possess specific binding interactions allowing spatial segregation of protein on a single particle. Additionally, these particles can possess other non-biological and unique functionalities based on choice of metal, such as magnetic and antimicrobial properties, which have been briefly explored. Overall, this work demonstrates a novel methodology for the creation of a spatially segregated particle platform which is easily reconfigurable, thus allows for multiple types of applications.
