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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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"Resveratrol Contrast Cancer Cell Invasion through Induction of Autophagy: Mechanisms and Pathways"
Ciro Isidoro, M.D., Ph.D.
Associate Professor
Department of General Pathology
Università del Piemonte Orientale
Resveratrol is a naturally occurring polyphenol with the potential to inhibit cancer cell migration. Here we show that Resveratrol counteracts the cell migration and invasion stimulatory effects of IL-6 (a cytokine released by cancer associated fibroblasts) and of Lysophosphatidic acid (LPA, a small phospholipid released by cancer cells), both known to promote ovarian cancer metastasis. Transcriptomic and microRNomic analyses showed that Resveratrol and IL-6 regulated in an opposite manner the expression of RNA messengers and of microRNAs involved in cell locomotion and extracellular matrix remodeling associated with the invasive properties of ovarian cancer cells. Further, Resveratrol and LPA regulated in an opposite manner the expression of Bmi-1, a polycomb protein of the HedgeHog pathway involved in cancer cell stemness and metastasis. We show that the pathways triggered by Resveratrol converge in the activation of autophagy in cancer cells and that this process is sufficient to inhibit cancer cell migration and invasion.
