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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Yali Dou, Ph.D
Associate Professor
Department of Pathology
Department of Biological Chemistry
University of Michigan
Abstract:
Epigenetics refers to heritable changes that are not encoded in the DNA sequence. It has emerged that histones, the basic building blocks of the hierarchical chromatin structure in eukaryotes, are major carriers of epigenetic information. The evolutionarily conserved covalent modifications such as histone methylation play important roles in chromatin-template based processes including transcrition, replication and DNA damge repair. Mutations in histone methyltransferases are frequently found in human malignancies. Our research focuses on MLL family histone methyltransferases ant their roles in cell fate determination during physiological and maligant proceses. Using combined bioichemistry, genetic and chemical biology approaches, we have uncovered novel mechanisms by which MLL function in cells and establish MLL as a potential therapeutic target in leukemia.
