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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Summary Sentence: BME Speaker Seminar with Kyle Allison, Ph.D.*
Full Summary: No summary paragraph submitted.
Kyle Allison, Ph.D.**** FACULTY CANDIDATE ***
DSB Fellow
Department Systems Biology
Columbia University
ABSTRACT
Antibiotics, which initiated the field of chemotherapy, have transformed human health and support nearly every branch of medicine. Challenges like antibiotic tolerance, genetic antibiotic resistance, and off-target drug toxicity demonstrate that current therapies are imperfect and that optimization of existing drugs is critical. My research has focused on reverse engineering drug tolerance and developing novel antibacterial approaches. In my symposium, I will discuss two representative projects focusing on persistent bacteria, a form of phenotypic heterogeneity in which a subpopulation of cells are highly tolerant to antibiotic treatment despite lacking genetic resistance mechanisms. The first project was the development of a metabolite-based approach to eradicate antibiotic persistent bacteria using aminoglycoside antibiotics. The second project utilized large-field microscopy to study the single-cell dynamics of persistent bacteria. Overall, my research uses systems approaches to understand and optimize antibiotic chemical biology, and will be extended to additional forms of chemotherapy.
Host: Andres Garcia, Ph.D.
10:30 a.m.
McIntire Room 3115,
Whitaker Bldg.
Videoconference:
Emory: HSRB E182
Georgia Tech: TEP 104
