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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Hydrogen sulfide is a signaling molecule that is toxic at high levels. We have demonstrated that the H2S-producing enzymes are remarkably promiscuous and that allosteric mechanisms exist to switch their reaction specificity. The sulfide oxidation pathway resides in the mitochondrion, generates reactive sulfur intermediates, and couples to the electron transfer chain, thus making H2S the only known inorganic substrate for ATP synthesis in mammals. Our discovery of novel heme-dependent sulfide oxidation chemistry will be discussed along with a proteomic approach that is revealing persulfidation targets in colon, which is routinely exposed to high sulfide concentrations from sulfate reducing bacteria in the microbiome.
