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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Karolin Luger
HHMI Investigator
Jennie-Smoly-Caruthers Endowed Chair of Chemistry and Biochemistry
University of Colorado
Abrstact:
Nucleosome assembly in the wake of DNA replication is a key process that regulates cell identity and survival. Chromatin assembly factor 1 (CAF-1) is a H3-H4 histone chaperone that associates with the replisome and orchestrates chromatin assembly following DNA synthesis. Little is known about the mechanism and structure of this key complex. We investigate CAF-1 – histone binding modes and describe an intriguing ‘snap-on’ mechanism by which CAF-1 assembles nucleosomes.
In contrast to eukaryotes, many archaea have histone-based chromatin that does not require assembly factors. I will present the structure of archaeal chromatin, and discuss possible implications for the origins of the eukaryotic nucleosome.
A lunch reception will follow the seminar in EBB 5029 at 12 PM.
