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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Summary Sentence: BME Speaker Seminar with Lukasz Bugaj, Ph.D.*
Full Summary: No summary paragraph submitted.
Lukasz Bugaj, Ph.D.**** FACULTY CANDIDATE ***
Arnold O. Beckman Postdoctoral Fellow,
University of California, San Francisco
ABSTRACT
Despite decades of cell signaling studies, we have a limited understanding of the cell signaling code: how can cells make diverse and complex decisions using only a small set of intracellular signaling pathways? An intriguing hypothesis is that cells can decode the strength, dynamics, or combinations of intracellular signals. Optogenetic – or light activatible – tools now enable us to test this hypothesis through precise and tunable control over signaling inputs in living cells. These tools allow us to reverse-engineer the cell, giving fundamental insight into both 1) the cellular machinery and 2) the cell’s ability to process and interpret its dynamic environment. In this talk, I will first describe the engineering of optogenetic proteins for cell signaling, as well as their high-throughput implementation. I will then show how these approaches are revealing principles by which signaling dynamics govern cell fate decisions from neurogenesis to cancer cell proliferation.
Host: Edward Botchwey, Ph.D.
Thursday, February 16
10:30 a.m.
McIntire Room 3115,
Whitaker Bldg.
Videoconference:
Emory: HSRB E182
Georgia Tech: TEP 104
