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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Summary Sentence: BME School Chair Candidate: Andre Levchenko
Full Summary: No summary paragraph submitted.
Andre Levchenko
BME School Chair Candidate
Andre Levchenko
John C. Malone Professor of Biomedical Engineering
Founding Director, Yale Systems Biology Institute
Founding Director, Yale Cancer Systems Biology Center
Yale University
"A Systems Analysis of Cell Response to Complex Micro-environments:
from Fundamental Science to Clinical Applications"
Living cells do not exist in isolation. Rather they are tightly integrated with their environment, which supplies a host of biochemical and mechanical cues. These cues are processed by sophisticated signaling and regulatory networks which enable conditioning of cellular behavior and decision making on the past, current and future states of the cell environments. Malfunctioning of these signaling and decision making mechanisms is frequently related to the onset and progression of various pathologies. In this talk, I will highlight the current views on how cells and tissues process extracellular signals and respond to them, focusing in particular on the role of topography of extracellular matrix. I will introduce newly discovered phenomena, including Topotaxis, and emphasize how these new findings can help explain the relative contributions of genetics, biochemistry and biomechanics to diverse healthy and disease tissue states. Finally, I will explain how this approach has lent itself to development of novel diagnostic tests and drug development to control aggressive cancers.
Please see complete interview schedule at www.feedback.coe.gatech.edu.
Questions: BME-search@coe.gatech.edu
