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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Location:
New 1st COE Building,Room 208 (PKU campus at Beijing)
Emory HSRB E459 (GT campus at Atlanta)
Advisor:
Jeff Jianzhong Xi, PhD, Department of Biomedical Engineering, Peking University
Michael E. Davis, PhD, Department of Biomedical Engineering, Georgia Institute of Technology & Emory University
Committee Members:
Huaiqiu Zhu, PhD, Department of Biomedical Engineering, Peking University
Haifeng Chen, PhD, Department of Biomedical Engineering, Peking University
Yangming Wang, PhD, Institute of Molecular Medicine, Peking University
Title: Nox2-NAPDH oxidase associated miRNAs screening and delivery with nanoparticles for cardiac function recovery after myocardial infarction
Abstract: NAPDH oxidase with Nox2 is a major source for cardiac reactive oxygen species (ROS) production, which plays a key role in the pathogenesis of cardiac remodeling leading to heart failure. The expression of NOX2 is significantly increased after myocardial infarction (MI), especially in macrophages and myocytes. Evidences show that mice lacking the NOX2 gene are well recovered after heart injury. Here we use a high-throughput screening method to identify miRNAs that negatively regulate NOX2 expression. Moreover, we demonstrate polyketal nanoparticles as delivery vehicles for miRNAs to macrophages in vitro and to post-MI heart in vivo to improving cardiac function.
