Ian Ehrenreich, USC

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Event Details
  • Date/Time:
    • Thursday March 31, 2016 - Friday April 1, 2016
      3:00 pm - 2:59 pm
  • Location: Georgia Tech, EBB 1005
  • Phone: (404) 894-3700
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

If you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biology's administrative office at bio-admin@biology.gatech.edu.

Summaries

Summary Sentence: Ian Ehrenreich, USC

Full Summary: Abstract:Cryptic genetic variants that do not typically influence traits can interact with each other, the environment, and mutations to cause unexpected phenotypes. The genetic architectures and molecular mechanisms that underlie these interactions are not well understood. To help advance knowledge in this area, we comprehensively dissected the genetic basis of a cryptic yeast colony trait across multiple mutant backgrounds and environments in a yeast cross. Across our studies, we identified 12 specific genes and 6 uncharacterized loci that harbor cryptic variants, as well as 7 ‘capacitor’ genes that can reveal these cryptic variants when mutated. Additionally, we defined specific, complex combinations of epistatically interacting cryptic variants that can lead to the colony phenotype in particular mutant backgrounds or environments. Most of the identified capacitors and genes harboring cryptic variants act in the evolutionarily conserved and oncogenic Ras signaling cascade, and appear to influence the activities of antagonistic, Ras-regulated transcription factors. Thus, our results suggest that complicated genetic and environmental influences on gene regulatory networks play a key role in suppressing and uncovering cryptic phenotypes.

Roles of genetic variation, mutations, and environment in uncovering a cryptic phenotype

Additional Information

In Campus Calendar
No
Groups

School of Biological Sciences

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
Greg Gibson, School of Biology
Status
  • Created By: Jasmine Martin
  • Workflow Status: Published
  • Created On: Dec 16, 2015 - 9:51am
  • Last Updated: Apr 13, 2017 - 5:17pm