Liang Han, John Hopkins University

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Event Details
  • Date/Time:
    • Thursday January 22, 2015 - Friday January 23, 2015
      10:00 am - 9:59 am
  • Location: Klaus Advanced Computing Building, 1116W
  • Phone: (404) 894-3700
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

If you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biology's administrative office at bio-admin@biology.gatech.edu.

Summaries

Summary Sentence: Liang Han, John Hopkins University

Full Summary: Molecular and Cellular Mechanisms of Itch SensationItch, or pruritus, is defined as the unpleasant sensation that elicits the desire or reflex to scratch. Chronic itch accompanying cutaneous disease or system disorders affects millions of patients. Itch sensation is detected by the primary sensory neurons in dorsal root ganglia (DRG) which transmit the signals to the central nervous system. The molecular identity of itch-sensing DRG neurons has been a fundamental but puzzling question. Using a combination of mouse genetic tools as well as molecular, cellular, and behavioral approaches, I demonstrated that MrgprA3, a member of the Mas-related G protein-coupled receptors (Mrgprs) family, is a molecular marker to label itch-sensing DRG neurons. Investigation of MrgprA3+ DRG neurons provided conceptual advances to the molecular and cellular mechanisms underlying itch sensation and opened new avenues for developing anti-pruritic therapies.

Molecular and Cellular Mechanisms of Itch Sensation

Additional Information

In Campus Calendar
No
Groups

School of Biological Sciences

Invited Audience
Undergraduate students, Faculty/Staff, Public, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
Greg Gibson, Liang Han, School of Biology Seminar
Status
  • Created By: Jasmine Martin
  • Workflow Status: Published
  • Created On: Dec 12, 2014 - 5:43am
  • Last Updated: Apr 13, 2017 - 5:20pm