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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Summary Sentence: "Post-translational Modifications: The Final Frontier of Protein Structure-function Relationships" - Matthew Torres, PhD - Georgia Tech
Full Summary: The Petit Institute Breakfast Club seminar series was started with the spirit of the Institute's interdisciplinary mission in mind and started to feature local Petit Institute faculty member's research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The Petit Institute Breakfast Club is open to anyone in the bio-community.
Breakfast Club Seminar Series"Post-translational Modifications: The Final Frontier of Protein Structure-function Relationships"
Matthew Torres, Ph.D.
Assistant Professor
School of Biology
Georgia Tech
My lab integrates mass spectrometry and experimental cell biology using the yeast model system to understand how networks of coordinated PTMs modulate biological function. Now well into the era of genomics and proteomics, it is widely appreciated that understanding individual genes or proteins, although necessary, is often not sufficient to explain the complex behavior observed in living organisms. Indeed, placing context on the dynamic network of relationships that exist between multiple proteins is now one of the greatest challenges in Biology. Post-translational modifications (PTMs, e.g. phosphorylation, ubiquitination and over 200 others), which can be readily quantified by mass spectrometry (MS), often mediate these dynamic relationships through enhancement or disruption of binding and/or catalytic properties that can result in changes in protein specificity, stability, or cellular localization.
