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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Hening Wang
PhD Proposal Presentation
Beijing time : 9:30 am November 14th, 2014
Location at Beijing: Wangkezhen building, meeting room 906
Atlanta time : 8:30 p m November 13th, 2014
Location at GT:TBD
Advisor:
Qiushi Ren, PhD (Peking University,BME)
Coadvisor :
Shuming Nie, PhD (Emory University and Georgia Institute of Technology,BME)
Committee:
Changhui Li, PhD (PKU, BME)
Kuangshi Chen, PhD (PKU, BME)
Mingyuan Gao, PhD ( Institute of Chemistry , Chinese Academy of Sciences)
Cancer Nanotechnology:
Development of Polymer-Coated Nanoparticle for Cancer Diagnosis and Imaging
ABSTRACT
Cancer is the second most common cause of death in the world. Significant progress has been made in the treatment and management of cancer. Yet, the major challenges remain because of the complexity nature of the disease. The improvement in survival rates not only relies on treatment, but also in early stage detection and diagnostics for certain cancers. Nanometer-sized particles have intrinsic optical, electronic, and structural properties thus provide advanced technology platforms for ultrasensitive and multiplexed detection of disease markers on the molecular level. However, high quality nanoparticles are often unsuited for use in complex biological environments because of their coatings and surface chemistry. Here, we propose to design and develop novel biocompatible Hyaluronic acid polymer coated nanoparticles for cancer targeted imaging applications. This goal will be accomplished through (1) synthesis and characterization of the Hyaluronic acid polymer coated nanoparticles; (2) in vitro cellular toxicity and targeting studies in cancer cell lines overexpressing the CD44 receptor; and (3) in vivo investigation in the nude mouse xenograft model and subsequent analysis of the effects on the tumor. The application of these nanoparticles can be extended to design multifunctional nanostructures and will have a significant impact on cancer diagnostics, molecular profiling, and the integration of cancer therapy and imaging.
