Annalise Paaby, New York University

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Event Details
  • Date/Time:
    • Thursday November 6, 2014 - Friday November 7, 2014
      10:00 am - 9:59 am
  • Location: Georgia Tech, Klaus Advanced Computing Building, 1116W
  • Phone: (404) 894-3700
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

If you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biology's administrative office at bio-admin@biology.gatech.edu.

Summaries

Summary Sentence: Annalise Paaby, New York University

Full Summary: Cryptic genetic variation and genetic complexity in the evolution of quantitative traitsAbstract:Conditionally functional mutations are an important class of natural genetic variation, yet little is known about their prevalence in natural populations or their contribution to disease risk. In this talk I describe a vast reserve of cryptic genetic variation, alleles that are normally silent but which affect phenotype when the function of other genes is perturbed, in the gene networks of C. elegans embryogenesis. I find evidence that cryptic-effect loci are ubiquitous and segregate at intermediate frequencies in the wild. The cryptic alleles demonstrate low developmental pleiotropy, in that specific, rather than general, perturbations are required to reveal them. My findings underscore the importance of genetic background in characterizing gene function and provide a model for the expression of conditionally functional effects that may be fundamental in basic mechanisms of trait evolution and the genetic basis of disease susceptibility.

Cryptic genetic variation and genetic complexity in the evolution of quantitative traits

Additional Information

In Campus Calendar
No
Groups

School of Biological Sciences

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
Annalise Paaby, Greg Gibson, School of Biology Seminar
Status
  • Created By: Jasmine Martin
  • Workflow Status: Published
  • Created On: Oct 29, 2014 - 4:45am
  • Last Updated: Apr 13, 2017 - 5:21pm