Sergey Kryazhimskiy, Harvard University

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Event Details
  • Date/Time:
    • Thursday September 11, 2014 - Friday September 12, 2014
      11:00 am - 10:59 am
  • Location: Georgia Tech, Klaus Advanced Computing Building, 1116W
  • Phone: (404) 894-3700
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

If you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biology's administrative office at bio-admin@biology.gatech.edu.

Summaries

Summary Sentence: Epistasis and predictability of adaptation

Full Summary: Epistasis and predictability of adaptationPopulations adapt to their environment by accumulating beneficial mutations, but predicting evolutionary outcomes is difficult because the effects of new mutations are contingent on prior mutations. We carried out an evolution experiment in budding yeast that quantifies this contingency. We evolved 10 populations starting from each of 64 founder strains that previously accumulated a small number of mutations. Sequencing of the evolved clones revealed that each population took a unique mutational trajectory towards higher fitness. Despite this diversity at the genetic level, different founders adapted at highly predictable rates that were determined by their initial fitness. We found that this remarkable predictability of fitness trajectories despite randomness at the sequence level occurs because the effects of new mutations on fitness depend only on the fitness of the strain in which they occur, but not on the specific prior mutations in that strain. Thus, while it may be impossible to predict which specific mutations a population will acquire during evolution, epistasis can channel the corresponding phenotypic changes towards a limited number of outcomes and thereby make phenotypic evolution predictable.

Epistasis and predictability of adaptation

Additional Information

In Campus Calendar
Yes
Groups

School of Biological Sciences

Invited Audience
Undergraduate students, Faculty/Staff, Public, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
Joshua Weitz, School of Biology Seminar, Sergey Kryazhimskiy
Status
  • Created By: Jasmine Martin
  • Workflow Status: Published
  • Created On: Sep 4, 2014 - 12:56pm
  • Last Updated: Apr 13, 2017 - 5:21pm