Yu-Qing Cao, Washington University

*********************************
There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
*********************************

Event Details
  • Date/Time:
    • Thursday September 18, 2014 - Friday September 19, 2014
      11:00 am - 10:59 am
  • Location: Georgia Tech, Klaus Advanced Computing Building, 1116W
  • Phone: (404) 894-3700
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

If you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biology's administrative office at bio-admin@biology.gatech.edu.

Summaries

Summary Sentence: Calcium channels and migraine headache

Full Summary: Yu-Qing Cao, Department of Anesthesiology and Pain Center, Washington University in St. LouisAbstract:
Migraine headache is highly debilitating, poorly understood, and difficult to treat. Mutations of human P/Q-type voltage-gated Ca2+ channels (VGCCs) associated with familial hemiplegic migraine type 1 (FHM-1) offer a gateway toward understanding the pathophysiology of FHM-1 as well as common migraine. Loss-of-function P/Q channel mutations cause a decrease of P/Q-type current in all subtypes of primary afferent neurons (PANs) in the pain pathways. Interestingly, only the PANs encoding headache become hyper-excitable as the result of P/Q mutations, consistent with the fact that FHM-1 patients show higher incidence of migraine headache but not other types of pain. Additional studies using a mouse model of headache suggest that P/Q and other VGCCs are involved in the onset of migraine in general population, not just FHM-1 patients. Ongoing experiments focus on dissecting the contribution of individual VGCC subtypes to migraine pathophysiology and their potential as targets for new migraine therapeutics.

Calcium channels and migraine headache

Additional Information

In Campus Calendar
No
Groups

School of Biological Sciences

Invited Audience
Undergraduate students, Faculty/Staff, Public, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
School of Biology Seminar, Yu-Qing Cao, Yuhong Fan
Status
  • Created By: Jasmine Martin
  • Workflow Status: Published
  • Created On: Aug 6, 2014 - 5:20am
  • Last Updated: Apr 13, 2017 - 5:22pm