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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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In addition to its annual lectures, ChBE hosts a weekly seminar throughout the year with invited lecturers who are prominent in their fields. Unless otherwise noted, all seminars are held on Wednesdays in the Molecular Science and Engineering Building ("M" Building) in G011 (Cherry Logan Emerson Lecture Theater) at 4:00 p.m. Refreshments are served at 3:30 p.m. in the Emerson-Lewis Reception Salon.
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Multitasking Anti-Cancer Biotherapeutics
Combining multiple binding domains into single macromolecular assemblies enables novel approaches to cancer therapeutic development. Examples of such multispecific strategies will be presented including: pretargeted radioimmunotherapy; triepitopic receptor clustering and downregulation; and targeted endosomal potentiation for macromolecular payload release. The primary synthetic approach is to use combinatorial libraries of protein displayed on the surface of yeast cells, and to select the desired binding properties by directed evolution. A common analytical thread throughout this work is to formulate simple, reductionist kinetic schema for these complex systems that help to elucidate key parameters and rate processes.
