Martin Walsh, Icahn School of Medicine at Mount Sinai

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Event Details
  • Date/Time:
    • Tuesday March 25, 2014 - Wednesday March 26, 2014
      8:00 pm - 8:59 pm
  • Location: Parker H. Petit Institute for Bioengineering & Bioscience, Room 1128
  • Phone: (404) 894-3700
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

If you have questions about logistics or would like to set up an appointment with a speaker, please contact the School of Biology's Administrative office at bio-admin@biology.gatech.edu.

Summaries

Summary Sentence: Regulating Energy and Lipid Metabolism through Pluripotent Transcriptional Networks

Full Summary: Abstract:
Glycolysis and lipid biosynthesis are crucial to stem cell behavior, but we know little about the transcriptional regulation of factors driving metabolism in concert with stem cell fate. We demonstrate through use of selective BET-bromodomain inhibitors, and comprehensive RNA-seq and ChIP-seq analysis in mouse embryonic stem cells (ESCs), that Brd4, a master chromatin reader, governs transcription of the core pluripotency network and genes required for lipogenesis. Our studies now show that Brd4 governs glycolysis and lipogenesis at the core of the pluripotency framework of genes and that Brd4 regulates critical nodes of metabolism leading to the production of co-factors needed for modifying the epigenome.

Title: Regulating Energy and Lipid Metabolism through Pluripotent Transcriptional Networks

Additional Information

In Campus Calendar
No
Groups

School of Biological Sciences

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
Integrated Cancer Research Center, John McDonald, Martin Walsh, School of Biology Seminar
Status
  • Created By: Jasmine Martin
  • Workflow Status: Published
  • Created On: Mar 20, 2014 - 8:38am
  • Last Updated: Apr 13, 2017 - 5:22pm