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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Summary Sentence: "From Signals to Shapes in Tissue Morphogenesis" - Stanislav Y. Shvartsman, PhD - Princeton University
Full Summary: The Bioengineering Seminar Series is a joint seminar series between Petit Institute and the Wallace H. Coulter Department of Biomedical Engineering. Seminars are held on Tuesdays or Thursdays between 11am-12pm in Petit Institute 1128 unless otherwise indicated.
Yanislav Y. Shvartsman, PhD
Bioengineering Seminar Series"From Signals to Shapes in Tissue Morphogenesis"
Stanislav Y. Shvartsman, PhD
Professor of Chemical and Biological Engineering
Princeton University
Regulated folding of two-dimensional cell sheets (epithelia) is one of the main mechanisms underlying the emergence of three-dimensional structures of tissues and organs. Mechanisms of epithelial morphogenesis have been highly conserved in evolution and can be largely driven by two-dimensional patterning of mechanical properties of cells comprising the epithelium. My group is interested in establishing quantitative models of epithelial morphogenesis, accounting for multiple layers of regulation, from gene sequence to tissue architecture. I will present some of our recent results in this area, focusing on imaging, modeling, and computational analysis of two-dimensional pattern formation and three-dimensional morphogenesis in the developing Drosophila egg, a powerful system for studying how chemical signals induce complex three-dimensional structures.
The main focus of our work is on the quantitative analysis of development. Our goal is to establish models that connect multiple levels of description, from gene sequence to pattern formation and morphogenesis. We emphasize close coupling between genetic experiments, computations, and theory, and use the fruit fly as an experimental system for model validation.
Faculty host: Hang Lu
