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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Summary Sentence: "Therapeutic Angiogenesis and Bone Regeneration with Natural and Synthetic Small Molecules" - Ed Botchwey, PhD - Associate Professor, Wallace H. Coulter Department of Biomedical Engineering
Full Summary: The IBB Breakfast Club seminar series was started with the spirit of the Institute's interdisciplinary mission in mind and started to feature local IBB faculty member's research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The IBB Breakfast Club is open to anyone in the bio-community.
Breakfast Club Seminar Series"Therapeutic Angiogenesis and Bone Regeneration with Natural and Synthetic Small Molecules"
Ed Botchwey, PhD
Associate Professor
Wallace H. Coulter Department of Biomedical Engineering
Endothelial cells play significant roles in conditioning the environment in local tissues after injury by the production and secretion of angiocrine factors. At least two distinct subsets of leukocytes, CD45+ CD11b+ Ly6C+Gr1+CX3CR1lo inflammatory monocytes (IM) and CD45+CD11b+Ly6CGr1-CX3CR1hi anti-inflammatory monocytes (AM), respond differentially to these angiocrine factors and promote pathogen/debris clearance and angiogenesis/wound healing, respectively. Our laboratory is currently investigating how local sphingosine 1-phosphate receptor 3 (S1P3) agonism recruits AM to remodeling vessels. We employ micron and nanoscale biomaterials to deliver FTY720, a S1P1/3 agonist, to inflamed and ischemic tissues, to reduce in pro-inflammatory cytokine secretion and an increase in regenerative cytokine secretion. The altered balance of cytokine secretion results in a reduction in inflammatory monocyte recruitment and an increase in anti-inflammatory CX3CR1hi monocyte recruitment to a pro-regenerative perivascular niche. Increased S1P3 expression and activation on AM resulted in significantly enhanced SDF-1α chemotaxis over IM. AM recruitment also enhanced arteriolar diameter expansion and increased length density of the local vasculature: classic signs of vascular remodeling. This work establishes a role for S1P receptor signaling in the local conditioning of tissues by angiocrine factors that preferentially recruit regenerative monocytes that can enhance healing outcomes, bone tissue regeneration, and biomaterial implant functionality.
