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There is now a CONTENT FREEZE for Mercury while we switch to a new platform. It began on Friday, March 10 at 6pm and will end on Wednesday, March 15 at noon. No new content can be created during this time, but all material in the system as of the beginning of the freeze will be migrated to the new platform, including users and groups. Functionally the new site is identical to the old one. webteam@gatech.edu
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Prof. Christopher Jaroniec, The Ohio State University
Solid-state NMR spectroscopy of protein assemblies
School Colloquium
Solid-state nuclear magnetic resonance has recently emerged as a unique spectroscopic tool, with great potential for generating atomic-resolution images of macromolecular assemblies that do not readily lend themselves to analysis by traditional high-resolution approaches. I will introduce the key aspects of magic-angle spinning solid-state NMR spectroscopy and describe the results of our recent studies aimed at providing molecular level insights into the mechanisms of fundamental biological phenomena that involve large protein-protein or protein-nucleic acid complexes, including prion and amyloid strains and transmissibility barriers linked to protein misfolding diseases as well as DNA compaction in chromatin. I will also highlight applications of this NMR methodology to the structural analysis of self-assembled organic nanomaterials formed from small molecule precursors, and discuss the development of a new class of magic-angle spinning NMR techniques for the rapid determination of protein structures in the solid phase based on the use of covalently-attached paramagnetic tags.
For more information contact Prof">mailto:lyon@gatech.edu">Prof. Andrew Lyon (404-894-4090).
